SLEEP · PEPTIDE
What is DSIP?
Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026
THE SHORT ANSWER
DSIP, or delta sleep-inducing peptide, is a naturally occurring peptide of nine amino acids first isolated in the 1970s. It is studied for sleep and stress, though results have been inconsistent.
DSIP at a glance
- Type
- Peptide
- Also known as
- Delta sleep-inducing peptide
- Mechanism
- Delta sleep-inducing neuropeptide
- Status
- Investigational
- Half-life
- Minutes
- Route
- Subcutaneous
- Dosing range in the literature
- 100–250 mcg before bed
- Onset
- Same night to 1 week
- Storage
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date
How DSIP works
It was named for promoting slow-wave sleep in early animal experiments. Its receptor and exact mechanism remain unidentified, and it appears to interact with stress-hormone and other signalling systems.
What DSIP is studied for
- Sleep architecture
- Stress
Small human studies from the 1980s reported improved sleep in some people with insomnia, but later work was inconsistent. It has not been developed into an approved medicine.
Being studied for something is not proof that it works. Results in individuals vary.
DSIP dosing
Published protocols describe 100–250 mcg before bed, nightly or several nights weekly, given subcutaneous. Onset is typically reported at same night to 1 week.
These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.
DSIP side effects and risks
- Morning grogginess
- Injection-site reactions
- Limited human trial data
Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.
Is DSIP FDA approved?
Investigational. Not FDA-approved.
Approval and trial status change. This page was last reviewed on October 1, 2026.
DSIP at G1 Peptides
G1 Peptides does not currently supply DSIP. A provider can discuss alternatives in a free consultation.
DSIP questions
- What is DSIP?
- DSIP, or delta sleep-inducing peptide, is a naturally occurring peptide of nine amino acids first isolated in the 1970s. It is studied for sleep and stress, though results have been inconsistent.
- What is DSIP used for?
- DSIP is studied for sleep architecture and stress. Small human studies from the 1980s reported improved sleep in some people with insomnia, but later work was inconsistent. It has not been developed into an approved medicine.
- How does DSIP work?
- It was named for promoting slow-wave sleep in early animal experiments. Its receptor and exact mechanism remain unidentified, and it appears to interact with stress-hormone and other signalling systems.
- Is DSIP FDA approved?
- Investigational. Not FDA-approved.
- What is the typical DSIP dosage?
- Published protocols describe 100–250 mcg before bed, given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.
- What are the side effects of DSIP?
- Risks noted for DSIP include morning grogginess, injection-site reactions, and limited human trial data. Tell your provider about your medications and conditions before starting.
- What is the half-life of DSIP?
- The reported half-life is minutes. Onset is typically reported at same night to 1 week.
- How should DSIP be stored?
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date.
For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.