ANTI-AGING · PEPTIDE
What is Epithalon?
Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026
THE SHORT ANSWER
Epithalon is a synthetic peptide of four amino acids, modelled on an extract of the pineal gland. It is studied in aging research, mainly for its reported effect on telomerase, the enzyme that maintains the protective ends of chromosomes.
Epithalon at a glance
- Type
- Peptide
- Also known as
- Epitalon, Epithalone, AEDG peptide
- Mechanism
- Pineal tetrapeptide; studied for telomerase activation
- Status
- Compounded (Rx)
- Half-life
- Short (limited data)
- Route
- Subcutaneous
- Dosing range in the literature
- 5–10 mg daily (10–20 day cycles)
- Onset
- Weeks (cycle-based)
- Storage
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date
How Epithalon works
In cell studies it activates telomerase and lengthens telomeres. It is also reported to influence melatonin release and circadian rhythm, in keeping with its origin in pineal research.
What Epithalon is studied for
- Healthy aging
- Sleep & circadian rhythm
Most research comes from one group of Russian investigators and from cell and animal studies. Independent, controlled human trials are lacking, so its effect on aging in people is unproven.
Being studied for something is not proof that it works. Results in individuals vary.
Epithalon dosing
Published protocols describe 5–10 mg daily (10–20 day cycles), daily during cycles; 1–2 cycles yearly, given subcutaneous. Onset is typically reported at weeks (cycle-based).
These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.
Epithalon side effects and risks
- Injection-site reactions
- Limited Western trial data
Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.
Is Epithalon FDA approved?
Not FDA-approved.
Approval and trial status change. This page was last reviewed on October 1, 2026.
Epithalon at G1 Peptides
G1 Peptides supplies Epithalon as vials (10 mg, 50 mg). Prescription products ship only after a licensed provider has reviewed the order.
Epithalon questions
- What is Epithalon?
- Epithalon is a synthetic peptide of four amino acids, modelled on an extract of the pineal gland. It is studied in aging research, mainly for its reported effect on telomerase, the enzyme that maintains the protective ends of chromosomes.
- What is Epithalon used for?
- Epithalon is studied for healthy aging and sleep & circadian rhythm. Most research comes from one group of Russian investigators and from cell and animal studies. Independent, controlled human trials are lacking, so its effect on aging in people is unproven.
- How does Epithalon work?
- In cell studies it activates telomerase and lengthens telomeres. It is also reported to influence melatonin release and circadian rhythm, in keeping with its origin in pineal research.
- Is Epithalon FDA approved?
- Not FDA-approved.
- What is the typical Epithalon dosage?
- Published protocols describe 5–10 mg daily (10–20 day cycles), given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.
- What are the side effects of Epithalon?
- Risks noted for Epithalon include injection-site reactions and limited Western trial data. Tell your provider about your medications and conditions before starting.
- What is the half-life of Epithalon?
- The reported half-life is short (limited data). Onset is typically reported at weeks (cycle-based).
- How should Epithalon be stored?
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date.
For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.