COSMETIC · PEPTIDE
What is GHK-Cu?
Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026
THE SHORT ANSWER
GHK-Cu is a naturally occurring peptide of three amino acids bound to copper. It is found in human plasma, where its level falls with age, and it is studied for skin repair, collagen production and wound healing. It is widely used in skincare.
GHK-Cu at a glance
- Type
- Peptide
- Also known as
- Copper peptide, Copper tripeptide-1
- Mechanism
- Copper-binding tripeptide; collagen, elastin, and gene-expression signalling
- Status
- Compounded (Rx)
- Half-life
- Short (limited data)
- Route
- Subcutaneous or topical
- Dosing range in the literature
- 1–2 mg per dose
- Onset
- 4–12 weeks
- Storage
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date; blue tint is normal
How GHK-Cu works
It delivers copper to cells and acts as a signal that increases production of collagen, elastin and other components of the skin’s structure. Laboratory studies also show it changes the activity of many genes involved in repair and inflammation.
What GHK-Cu is studied for
- Skin & collagen
- Wound healing
- Hair support
Topical GHK-Cu has human studies showing improved skin firmness and reduced fine lines. Evidence for injected GHK-Cu is mostly from animal and laboratory work.
Being studied for something is not proof that it works. Results in individuals vary.
GHK-Cu dosing
Published protocols describe 1–2 mg per dose, daily or several times weekly, given subcutaneous or topical. Onset is typically reported at 4–12 weeks.
These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.
GHK-Cu side effects and risks
- Stinging on injection
- Transient fatigue
Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.
Is GHK-Cu FDA approved?
Used in cosmetics. Not FDA-approved as an injectable drug.
Approval and trial status change. This page was last reviewed on October 1, 2026.
GHK-Cu at G1 Peptides
G1 Peptides supplies GHK-Cu as vials (50 mg, 100 mg) and in pens (GLOW, KLOW). Prescription products ship only after a licensed provider has reviewed the order.
GHK-Cu questions
- What is GHK-Cu?
- GHK-Cu is a naturally occurring peptide of three amino acids bound to copper. It is found in human plasma, where its level falls with age, and it is studied for skin repair, collagen production and wound healing. It is widely used in skincare.
- What is GHK-Cu used for?
- GHK-Cu is studied for skin & collagen, wound healing, and hair support. Topical GHK-Cu has human studies showing improved skin firmness and reduced fine lines. Evidence for injected GHK-Cu is mostly from animal and laboratory work.
- How does GHK-Cu work?
- It delivers copper to cells and acts as a signal that increases production of collagen, elastin and other components of the skin’s structure. Laboratory studies also show it changes the activity of many genes involved in repair and inflammation.
- Is GHK-Cu FDA approved?
- Used in cosmetics. Not FDA-approved as an injectable drug.
- What is the typical GHK-Cu dosage?
- Published protocols describe 1–2 mg per dose, given subcutaneous or topical. This is context from the literature, not a recommendation: a licensed provider sets the dose.
- What are the side effects of GHK-Cu?
- Risks noted for GHK-Cu include stinging on injection and transient fatigue. Tell your provider about your medications and conditions before starting.
- What is the half-life of GHK-Cu?
- The reported half-life is short (limited data). Onset is typically reported at 4–12 weeks.
- How should GHK-Cu be stored?
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date; blue tint is normal.
For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.