SEXUAL HEALTH · PEPTIDE
What is Kisspeptin-10?
Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026
THE SHORT ANSWER
Kisspeptin-10 is the shortest active fragment of kisspeptin, a hormone that sits at the top of the reproductive hormone system. It triggers release of GnRH, which in turn raises LH, FSH and sex hormones.
Kisspeptin-10 at a glance
- Type
- Peptide
- Also known as
- Kisspeptin, Metastin 45-54
- Mechanism
- KISS1R agonist; stimulates GnRH release
- Status
- Compounded (Rx)
- Half-life
- Minutes
- Route
- Subcutaneous
- Dosing range in the literature
- 100–500 mcg per dose
- Onset
- Within hours (LH rise)
- Storage
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date
How Kisspeptin-10 works
It binds the KISS1 receptor on GnRH neurons in the brain. Because it works upstream, it stimulates the body’s own hormone production instead of replacing hormones directly.
What Kisspeptin-10 is studied for
- Reproductive hormone signalling
- Libido
Human studies show it raises LH and testosterone within hours. Research has explored fertility treatment and sexual and emotional brain responses. It remains investigational.
Being studied for something is not proof that it works. Results in individuals vary.
Kisspeptin-10 dosing
Published protocols describe 100–500 mcg per dose, intermittent, given subcutaneous. Onset is typically reported at within hours (LH rise).
These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.
Kisspeptin-10 side effects and risks
- Injection-site reactions
- Limited human trial data
Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.
Is Kisspeptin-10 FDA approved?
Not FDA-approved.
Approval and trial status change. This page was last reviewed on October 1, 2026.
Kisspeptin-10 at G1 Peptides
G1 Peptides supplies Kisspeptin-10 as vials (10 mg). Prescription products ship only after a licensed provider has reviewed the order.
Kisspeptin-10 questions
- What is Kisspeptin-10?
- Kisspeptin-10 is the shortest active fragment of kisspeptin, a hormone that sits at the top of the reproductive hormone system. It triggers release of GnRH, which in turn raises LH, FSH and sex hormones.
- What is Kisspeptin-10 used for?
- Kisspeptin-10 is studied for reproductive hormone signalling and libido. Human studies show it raises LH and testosterone within hours. Research has explored fertility treatment and sexual and emotional brain responses. It remains investigational.
- How does Kisspeptin-10 work?
- It binds the KISS1 receptor on GnRH neurons in the brain. Because it works upstream, it stimulates the body’s own hormone production instead of replacing hormones directly.
- Is Kisspeptin-10 FDA approved?
- Not FDA-approved.
- What is the typical Kisspeptin-10 dosage?
- Published protocols describe 100–500 mcg per dose, given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.
- What are the side effects of Kisspeptin-10?
- Risks noted for Kisspeptin-10 include injection-site reactions and limited human trial data. Tell your provider about your medications and conditions before starting.
- What is the half-life of Kisspeptin-10?
- The reported half-life is minutes. Onset is typically reported at within hours (LH rise).
- How should Kisspeptin-10 be stored?
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date.
For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.