IMMUNE · PEPTIDE
What is KPV?
Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026
THE SHORT ANSWER
KPV is a peptide of three amino acids, the active end of the hormone alpha-MSH. It is studied for anti-inflammatory effects, particularly in the gut and skin, without the pigment-darkening effect of the full hormone.
KPV at a glance
- Type
- Peptide
- Also known as
- Lys-Pro-Val, α-MSH (11-13)
- Mechanism
- α-MSH C-terminal tripeptide; anti-inflammatory signalling
- Status
- Compounded (Rx)
- Half-life
- Short (limited data)
- Route
- Subcutaneous (oral / topical studied)
- Dosing range in the literature
- 250–1,000 mcg per dose
- Onset
- 1–3 weeks
- Storage
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date
How KPV works
It enters cells and reduces the activity of NF-kB, a master switch for inflammatory signalling, which lowers the production of inflammatory molecules.
What KPV is studied for
- Gut inflammation
- Skin inflammation
Animal studies of colitis and skin inflammation show reduced inflammation. Human trials have not been carried out, so its effect in people is unestablished.
Being studied for something is not proof that it works. Results in individuals vary.
KPV dosing
Published protocols describe 250–1,000 mcg per dose, once daily, given subcutaneous (oral / topical studied). Onset is typically reported at 1–3 weeks.
These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.
KPV side effects and risks
- Injection-site reactions
- Limited human trial data
Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.
Is KPV FDA approved?
Not FDA-approved.
Approval and trial status change. This page was last reviewed on October 1, 2026.
KPV at G1 Peptides
G1 Peptides supplies KPV as vials (10 mg) and in pens (KLOW). Prescription products ship only after a licensed provider has reviewed the order.
KPV questions
- What is KPV?
- KPV is a peptide of three amino acids, the active end of the hormone alpha-MSH. It is studied for anti-inflammatory effects, particularly in the gut and skin, without the pigment-darkening effect of the full hormone.
- What is KPV used for?
- KPV is studied for gut inflammation and skin inflammation. Animal studies of colitis and skin inflammation show reduced inflammation. Human trials have not been carried out, so its effect in people is unestablished.
- How does KPV work?
- It enters cells and reduces the activity of NF-kB, a master switch for inflammatory signalling, which lowers the production of inflammatory molecules.
- Is KPV FDA approved?
- Not FDA-approved.
- What is the typical KPV dosage?
- Published protocols describe 250–1,000 mcg per dose, given subcutaneous (oral / topical studied). This is context from the literature, not a recommendation: a licensed provider sets the dose.
- What are the side effects of KPV?
- Risks noted for KPV include injection-site reactions and limited human trial data. Tell your provider about your medications and conditions before starting.
- What is the half-life of KPV?
- The reported half-life is short (limited data). Onset is typically reported at 1–3 weeks.
- How should KPV be stored?
- Refrigerated (2–8 °C); use within the pharmacy beyond-use date.
For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.