What is the typical TB-500 dosage?

Published protocols describe 2–2.5 mg, twice weekly (loading), given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.

What are the side effects of TB-500?

Risks noted for TB-500 include injection-site reactions, transient fatigue or headache, and limited human trial data. Tell your provider about your medications and conditions before starting.

What is the half-life of TB-500?

The reported half-life is hours (limited human data). Onset is typically reported at 2–4 weeks.

How should TB-500 be stored?

Refrigerated (2–8 °C); use within the pharmacy beyond-use date.

HEALING · PEPTIDE

What is TB-500?

Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026

THE SHORT ANSWER

TB-500 is a synthetic peptide based on thymosin beta-4, a protein found in nearly all human cells that helps cells move and tissue repair itself. It is studied for soft-tissue recovery and wound healing and is not approved by the FDA.

TB-500 at a glance

Type: Peptide
Also known as: Thymosin Beta-4, Tβ4
Mechanism: Thymosin β4 fragment; actin binding, cell migration, angiogenesis
Status: Compounded (Rx)
Half-life: Hours (limited human data)
Route: Subcutaneous
Dosing range in the literature: 2–2.5 mg, twice weekly (loading)
Onset: 2–4 weeks
Storage: Refrigerated (2–8 °C); use within the pharmacy beyond-use date

How TB-500 works

Thymosin beta-4 binds actin, a building block of the cell skeleton. That promotes cell migration into injured tissue and the formation of new blood vessels, and it appears to dampen inflammation.

What TB-500 is studied for

Soft-tissue recovery
Reduced inflammation
Wound healing

Animal studies show improved healing of skin, heart, tendon and eye injuries. Human trials of thymosin beta-4 have focused on wound and eye healing; evidence for the uses it is popular for is limited.

Being studied for something is not proof that it works. Results in individuals vary.

TB-500 dosing

Published protocols describe 2–2.5 mg, twice weekly (loading), twice weekly, then every 1–2 weeks, given subcutaneous. Onset is typically reported at 2–4 weeks.

These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.

TB-500 dosage calculator →

TB-500 side effects and risks

Injection-site reactions
Transient fatigue or headache
Limited human trial data

Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.

Is TB-500 FDA approved?

Not FDA-approved for any use. Prohibited in sport by the World Anti-Doping Agency.

Approval and trial status change. This page was last reviewed on October 1, 2026.

TB-500 at G1 Peptides

G1 Peptides supplies TB-500 as vials (5 mg, 10 mg) and in pens (Wolverine, Wolverine-S, GLOW, KLOW, X-23). Prescription products ship only after a licensed provider has reviewed the order.

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TB-500 questions

What is TB-500?: TB-500 is a synthetic peptide based on thymosin beta-4, a protein found in nearly all human cells that helps cells move and tissue repair itself. It is studied for soft-tissue recovery and wound healing and is not approved by the FDA.
What is TB-500 used for?: TB-500 is studied for soft-tissue recovery, reduced inflammation, and wound healing. Animal studies show improved healing of skin, heart, tendon and eye injuries. Human trials of thymosin beta-4 have focused on wound and eye healing; evidence for the uses it is popular for is limited.
How does TB-500 work?: Thymosin beta-4 binds actin, a building block of the cell skeleton. That promotes cell migration into injured tissue and the formation of new blood vessels, and it appears to dampen inflammation.
Is TB-500 FDA approved?: Not FDA-approved for any use. Prohibited in sport by the World Anti-Doping Agency.
What is the typical TB-500 dosage?: Published protocols describe 2–2.5 mg, twice weekly (loading), given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.
What are the side effects of TB-500?: Risks noted for TB-500 include injection-site reactions, transient fatigue or headache, and limited human trial data. Tell your provider about your medications and conditions before starting.
What is the half-life of TB-500?: The reported half-life is hours (limited human data). Onset is typically reported at 2–4 weeks.
How should TB-500 be stored?: Refrigerated (2–8 °C); use within the pharmacy beyond-use date.

For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.