COMPARISON TOOL

Retatrutide vs AOD-9604 vs Tesamorelin vs MOTS-c

Four different routes to metabolic goals: appetite (retatrutide), fat metabolism (AOD-9604), visceral fat (tesamorelin), and mitochondrial signalling (MOTS-c).

RetatrutideAOD-9604TesamorelinMOTS-c

Max 4 peptides

Property	Retatrutide	AOD-9604	Tesamorelin	MOTS-c
Category	GLP-1	Metabolic	Growth	Metabolic
Type	Peptide	Peptide	Peptide	Peptide
Mechanism	Triple agonist (GLP-1 / GIP / glucagon)	hGH fragment 176–191; lipolytic signalling without growth effects	Stabilized GHRH analog	Mitochondrial-derived peptide; AMPK activation
Status	Phase 3	Compounded (Rx)	FDA-approved	Compounded (Rx)
Dosing range	1–12 mg weekly	250–600 mcg daily	1–2 mg daily	2.5–10 mg per dose
Frequency	Once weekly	Once daily, morning fasted	Once daily	2–3× weekly
Half-life	~6 days	Short (limited human data)	~26–38 minutes	Limited human data
Route	Subcutaneous	Subcutaneous	Subcutaneous	Subcutaneous
Onset	1–4 weeks for appetite reduction	4–8 weeks	8–12 weeks (visceral fat)	2–4 weeks
Studied for	Weight management Liver fat reduction Appetite control Energy expenditure	Fat metabolism Body composition	Visceral fat reduction Triglycerides Growth hormone release	Metabolic health Insulin sensitivity Exercise performance
Key risks	Nausea Vomiting Diarrhea Constipation Modest heart-rate increase	Injection-site reactions Headache	Joint pain Swelling Glucose increase Injection-site reactions	Injection-site reactions Limited human trial data
Storage	Refrigerated (2–8 °C); use within the pharmacy beyond-use date	Refrigerated (2–8 °C); use within the pharmacy beyond-use date	Refrigerated (2–8 °C); use within the pharmacy beyond-use date	Refrigerated (2–8 °C); use within the pharmacy beyond-use date
Available at G1	Vials: 10 mgShop →	Vials: 5 mg, 10 mgPens: TesaTrim, Lean Recovery, Opti-LeanShop →	Vials: 10 mgPens: Fragment Apex, TesaTrimShop →	Vials: 10 mgPens: MitoforgeShop →
Tools	Dosage calculator →	Dosage calculator →	Dosage calculator →	Dosage calculator →

PROPERTY COMPARISON · RADAR

Profile shape

Editorial profile scores (0–10) for orientation — not clinical measurements.

TYPICAL DOSE RANGES

Dose envelope

Retatrutide1 mg – 12 mg

AOD-9604250 mcg – 600 mcg

Tesamorelin1 mg – 2 mg

MOTS-c2.5 mg – 10 mg

Typical per-dose range on a logarithmic scale. Your provider sets your dose.

For educational purposes only. Consult a licensed provider before starting any peptide protocol.