COMPARISON TOOL

Retatrutide vs CagriSema vs Survodutide vs Mazdutide

The pipeline beyond semaglutide and tirzepatide: a triple agonist, an amylin combination, and two GLP-1/glucagon dual agonists, all in late-stage trials.

RetatrutideCagriSemaSurvodutideMazdutide

Max 4 peptides

Property	Retatrutide	CagriSema	Survodutide	Mazdutide
Category	GLP-1	GLP-1	GLP-1	GLP-1
Type	Peptide	Peptide blend	Peptide	Peptide
Mechanism	Triple agonist (GLP-1 / GIP / glucagon)	Cagrilintide (amylin) + semaglutide (GLP-1)	Dual glucagon / GLP-1 receptor agonist	Dual GLP-1 / glucagon receptor agonist
Status	Phase 3	Phase 3	Phase 3	Phase 3
Dosing range	1–12 mg weekly	0.25–2.4 mg of each, weekly	0.6–4.8 mg weekly	3–9 mg weekly
Frequency	Once weekly	Once weekly	Once weekly	Once weekly
Half-life	~6 days	~7 days	~5–6 days (limited data)	~7 days (limited data)
Route	Subcutaneous	Subcutaneous	Subcutaneous	Subcutaneous
Onset	1–4 weeks for appetite reduction	1–4 weeks for appetite reduction	2–4 weeks for appetite reduction	2–4 weeks for appetite reduction
Studied for	Weight management Liver fat reduction Appetite control Energy expenditure	Weight management Appetite control Type 2 diabetes	Weight management MASH / liver fat	Weight management Liver fat reduction Type 2 diabetes
Key risks	Nausea Vomiting Diarrhea Constipation Modest heart-rate increase	Nausea Vomiting Diarrhea Constipation	Nausea Vomiting Diarrhea Constipation	Nausea Vomiting Diarrhea Constipation Heart-rate increase
Storage	Refrigerated (2–8 °C); use within the pharmacy beyond-use date	Refrigerated (2–8 °C); use within the pharmacy beyond-use date	Refrigerated (2–8 °C); use within the pharmacy beyond-use date	Refrigerated (2–8 °C); use within the pharmacy beyond-use date
Available at G1	Vials: 10 mgShop →	Not currently carried. Ask a provider	Not currently carried. Ask a provider	Not currently carried. Ask a provider
Tools	Dosage calculator →	Dosage calculator →	Dosage calculator →	Dosage calculator →

PROPERTY COMPARISON · RADAR

Profile shape

Editorial profile scores (0–10) for orientation — not clinical measurements.

TYPICAL DOSE RANGES

Dose envelope

Retatrutide1 mg – 12 mg

CagriSema500 mcg – 4.8 mg

Survodutide600 mcg – 4.8 mg

Mazdutide3 mg – 9 mg

Typical per-dose range on a logarithmic scale. Your provider sets your dose.

For educational purposes only. Consult a licensed provider before starting any peptide protocol.