What is the typical Sermorelin dosage?

Published protocols describe 200–500 mcg nightly, given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.

What are the side effects of Sermorelin?

Risks noted for Sermorelin include flushing, headache, and injection-site reactions. Tell your provider about your medications and conditions before starting.

What is the half-life of Sermorelin?

The reported half-life is ~10–20 minutes. Onset is typically reported at 1–2 weeks (sleep); 6–12 weeks (composition).

How should Sermorelin be stored?

Refrigerated (2–8 °C); use within the pharmacy beyond-use date.

GROWTH · PEPTIDE

What is Sermorelin?

Medically reviewed by the G1 Peptides clinical team · Updated October 1, 2026

THE SHORT ANSWER

Sermorelin is the first 29 amino acids of growth hormone-releasing hormone, the shortest piece that is fully active. It prompts the pituitary to release growth hormone and is often chosen as a first growth hormone peptide because it is short-acting and well studied.

Sermorelin at a glance

Type: Peptide
Also known as: GRF 1-29, Geref
Mechanism: GHRH (1–29) analog
Status: Compounded (Rx)
Half-life: ~10–20 minutes
Route: Subcutaneous
Dosing range in the literature: 200–500 mcg nightly
Onset: 1–2 weeks (sleep); 6–12 weeks (composition)
Storage: Refrigerated (2–8 °C); use within the pharmacy beyond-use date

How Sermorelin works

It binds the GHRH receptor and triggers a natural pulse of growth hormone. Because the body’s feedback loops stay intact, the release is self-limiting. It is usually given at night to align with the body’s largest natural pulse.

What Sermorelin is studied for

Growth hormone release
Sleep quality
Gentle starting point

It was used for years to diagnose and treat growth hormone deficiency in children. Studies in adults show raised growth hormone and IGF-1, with modest changes in body composition.

Being studied for something is not proof that it works. Results in individuals vary.

Sermorelin dosing

Published protocols describe 200–500 mcg nightly, once nightly, given subcutaneous. Onset is typically reported at 1–2 weeks (sleep); 6–12 weeks (composition).

These figures are context from the literature, not instructions. A licensed provider sets the dose and schedule for each patient.

Sermorelin dosage calculator →

Sermorelin side effects and risks

Flushing
Headache
Injection-site reactions

Tell your provider about every medication and condition before starting, and report anything unexpected. See peptide side effects and safety and who should not use peptides.

Is Sermorelin FDA approved?

Formerly FDA-approved as Geref; the brand was withdrawn for commercial reasons. Now supplied by compounding pharmacies.

Approval and trial status change. This page was last reviewed on October 1, 2026.

Sermorelin at G1 Peptides

G1 Peptides supplies Sermorelin as vials (10 mg, 20 mg) and in pens (Trinity Stack, Wolverine-S). Prescription products ship only after a licensed provider has reviewed the order.

Shop Sermorelin →

Sermorelin questions

What is Sermorelin?: Sermorelin is the first 29 amino acids of growth hormone-releasing hormone, the shortest piece that is fully active. It prompts the pituitary to release growth hormone and is often chosen as a first growth hormone peptide because it is short-acting and well studied.
What is Sermorelin used for?: Sermorelin is studied for growth hormone release, sleep quality, and gentle starting point. It was used for years to diagnose and treat growth hormone deficiency in children. Studies in adults show raised growth hormone and IGF-1, with modest changes in body composition.
How does Sermorelin work?: It binds the GHRH receptor and triggers a natural pulse of growth hormone. Because the body’s feedback loops stay intact, the release is self-limiting. It is usually given at night to align with the body’s largest natural pulse.
Is Sermorelin FDA approved?: Formerly FDA-approved as Geref; the brand was withdrawn for commercial reasons. Now supplied by compounding pharmacies.
What is the typical Sermorelin dosage?: Published protocols describe 200–500 mcg nightly, given subcutaneous. This is context from the literature, not a recommendation: a licensed provider sets the dose.
What are the side effects of Sermorelin?: Risks noted for Sermorelin include flushing, headache, and injection-site reactions. Tell your provider about your medications and conditions before starting.
What is the half-life of Sermorelin?: The reported half-life is ~10–20 minutes. Onset is typically reported at 1–2 weeks (sleep); 6–12 weeks (composition).
How should Sermorelin be stored?: Refrigerated (2–8 °C); use within the pharmacy beyond-use date.

For educational purposes only, and not medical advice. These statements have not been evaluated by the FDA. Nothing on this page is intended to diagnose, treat, cure, or prevent any disease. Use any compound only under the guidance of a licensed provider.